Star GLA (GNC): Full Drug Profile

Star GLA (GNC) - General Information

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5. [PubChem]

Pharmacology of Star GLA (GNC)

Dihomo gamma-linolenic acid or DHLA is an n-6 (omega-6) polyunsaturated fatty acid. It is comprised of 20 carbon atoms and three double bonds. DHLA is a byproduct of the 18 carbon gamma-linolenic acid (GLA). DHLA is then converted into prostaglandin E1 (PGE1). PGE1 inhibits platelet aggregation and also exerts a vasodilatory effect.

Additional information about Star GLA (GNC)

Star GLA (GNC) Indication

For nutritional supplementation, also for treating dietary shortage or imbalance

Mechanism Of Action

DHLA (or DGLA) is a precursor in the synthesis of prostaglandin E1 (PGE1) as well as the series-3 prostaglandins. It also serves as a precursor in the synthesis of eicosapentaenoic acid (EPA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-thrombogenic, anti-inflammatory and anti-atherogenic properties. PGE1 inhibits platelet aggregation and has a vasodilation action. DHLA has also been shown to reduce the production/activity of tumor necrosis factor alpha.

Generic Name

gamma-Homolinolenic acid

Synonyms

(8E,11E,14E)-8,11,14-Icosatrienoic acid; 8,11,14-Eicosatrienoic Acid; (Z,Z,Z)-8,11,14-Eicosatrienoic acid; cis-8,11,14-Eicosatrienoic acid; DGLA; Dihomo-gamma-linolenic acid; Homo-gamma-linolenic acid

Drug Category

Dietary supplement; Micronutrient

Drug Type

Small Molecule; Nutraceutical; Approved

Other Brand Names containing gamma-Homolinolenic acid

Tona-lean 1000 CLA (Action Labs); Star GLA (GNC);

Dosage Forms of Star GLA (GNC)

Capsule Oral

Chemical IUPAC Name

(8Z,11Z,14Z)-icosa-8,11,14-trienoic acid

Chemical Formula

C20H34O2

Organisms Affected

Humans and other mammals